A backbone amide protecting group for overcoming difficult sequences and suppressing aspartimide formation
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چکیده
منابع مشابه
A backbone amide protecting group for overcoming difficult sequences and suppressing aspartimide formation
A backbone amide bond protecting group, 2-hydroxy-4-methoxy-5-nitrobenzyl (Hmnb), improved the synthesis of aggregation and aspartimide-prone peptides. Introduction of Hmnb is automated and carried out during peptide assembly by addition of 4-methoxy-5-nitrosalicylaldehyde to the peptidyl-resin and on-resin reduction to the secondary amine. Acylation of the hindered secondary amine is aided by ...
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ژورنال
عنوان ژورنال: Journal of Peptide Science
سال: 2016
ISSN: 1075-2617,1099-1387
DOI: 10.1002/psc.2877